Sequoia Sciences
Sequoia Sciences Sequoia Sciences
High-throughput Natural Products Chemistry

About Us Science & Technologies Research & Development Publications Contact

Sequoia Sciences is a pharmaceutical company discovering and developing new medicines for the treatment of bacterial infections and cancers. Our development programs consist of small molecules targeting bacterial infections and cancers, and also vaccines for the treatment and prevention of recurrent urinary tract infections. Our goal is to improve the quality of life for those individuals significantly affected by recurrent and chronic bacterial infections and cancers.

Sequoia is engaged in research and development programs and collaborations with laboratories, universities, clinical research sites, and private businesses.  We have applied our microscale structure determination expertise to elucidate structures of natural products,  biosynthetic intermediates, and unexpected synthetic products for academic and industrial collaborators.  Contact us to determine the structure of your challenging compound.

Presentations | See All

Sequoia Sciences to Organize and Chair a Natural Product Conference in Cancun, Mexico.

Mark O'Neil-Johnson, VP of Analytical Chemistry, has been invited to organize and chair the third in the series of natural product conferences as hosted by Fusion Conferences out of London, England. The 4 day conference, entitled "The Interface of Science and Technology as Applied to Natural Product Research" will be held in Cancun, Mexico, March 20-23, 2017.

Recent Publications | See All

November, 2016: Williams, R., Martin, S., Lawrence, J., Norman, V., O'Neil-Johnson, M., Eldridge, G., Starks, C., "Isolation and Identification of the Novel Tubulin Polymerization Inhibitor Bifidenone," J. Nat. Prod., Accepted, Special Issue in Honor of Professor Phil Crews

August, 2015: Williams, R., Norman, V., O'Neil-Johnson, M., Woodbury, S., Eldridge, G., Starks, C., "Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum," J. Nat. Prod. 2015, 78, 2074-2086.

July, 2015: Augustin, M., Ruzicka, D., Shukla, A., Augustin, J., Starks, C., O'Neil-Johnson, M., McKain, M., Evans, B., Barrett, M., Smithson, A., Wong, G., Deyholos, M., Edger, P., Pires, J., Leebens-Mack, J., Mann, D., Kutchan, T., "Elucidating Steroid Alkaloid Biosynthesis in Veratrum californicum: Production of Verazine in Sf9 Cells," The Plant Journal, 2015, 82, 991-1003 - Identifying Biosynthetic Intermediates at the Microgram Scale

April, 2015: Zerbe, P., Rodriguez, S., Mafu, S., Chaing, A., Dullat, H., O'Neil-Johnson, M., Starks, C., Bohlmann, J., "Exploring Diterpene Metabolism in Non-Model Species: Transcriptome-Enabled Discovery and Functional Characterization of Labda-7,13E-Dienyl Diphosphate Synthase from Grindelia robusta," The Plant Journal, 2015, Accepted - Identifying Biosynthetic Intermediates at the Microgram Scale

March, 2015: Chemler, J., Tropathi. A., Hansen, D., O'Neil-Johnson, M., Williams, R., Starks, C., Park, S., Sherman, D., "Evolution of Efficient Modular Polyketide Synthases by Homeologous Recombination," JACS, 2015, Accepted - Identifying Biosynthetic Intermediates at the Microgram Scale