Sequoia Sciences is part of the American Society of Pharmacognosy conference July 29 to August 2, 2017 in Portland, Oregon. Scientists Mark O'Neil Johnson and Russell Williams will present.
Sequoia Sciences' Mark O'Neil-Johnson will offer a workshop on "Following the Path of a Natural Product Molecule (Extraction to Elucidation)" with Jimmy Yuk of Waters, Inc. The workshop will follow a compound as it travels the path of an extraction, purification and structure determination. Unique, insightful and powerful analytical techniques that can be employed in this process will be presented, focusing on theory and applications of technologies that utilize supercritical fluid and mass spectrometry imaging. Included in this workshop will be a presentation on “an approach to structure elucidation,” where Russell Williams will share insights to performing the artful task of uncovering a molecule's structure based on the analytical data acquired.
Russell Williams will also present the development of SQ1274, Sequoia’s top preclinical anticancer candidate. Bifidenone, the naturally ocurring compound that inspired the development of SQ1274, was originally isolated in minute quantities from a small tree in Gabon. The development path from initial discovery and structure elucidation through total synthesis, medicinal chemistry, and in vivo studies will be discussed.